NO inhibitory guaianolide-derived terpenoids from Artemisia argyi.

نویسندگان

  • Shu Wang
  • Jun Li
  • Jian Sun
  • Ke-wu Zeng
  • Jing-rong Cui
  • Yong Jiang
  • Peng-fei Tu
چکیده

An unusual dimeric guaianolide, artemilinin A (1) and a sesquiterpene-monoterpene lactone, isoartemisolide (2), were isolated from the leaves of Artemisia argyi. Their structures were elucidated on the basis of extensive spectroscopic analysis (IR, HR-ESIMS, 1D- and 2D-NMR), and the absolute configurations were determined by CD spectra and quantum chemical ECD calculation. Furthermore, in in vitro assay, compound 2 exhibited pronounced inhibition on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglial cells with an IC50 value of 4.00μM.

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عنوان ژورنال:
  • Fitoterapia

دوره 85  شماره 

صفحات  -

تاریخ انتشار 2013